The school was built over 100 years before the events of Big Hero 6. It is attended by various students who study in the fields of science and technology. Every year, the school holds a convention at its Exposition hall, where up and coming geniuses are meant to showcase new creations to receive acceptance into the university. Tadashi Hamada, GoGo Tomago, Wasabi, and Honey Lemon were in its robotics program headed by Professor Robert Callaghan, who was also a mentor to Tadashi. The position of its school mascot was filled by Fred. During the time the film takes place, Tadashi's brother Hiro presents his invention, Microbots at the showcase. An impressed Callaghan grants Hiro acceptance into the school. Following the end of the showcase however, Callaghan sets fire to the Showcase Hall through an unspecified method, forcing to everyone in the campus' vicinity to evacuate. It explodes just as Tadashi rushes in to save Callaghan, unaware that Callaghan wanted to steal the Microbots.
After the defeat and capture of Callaghan, Hiro begins to attend the school with GoGo, Honey, Wasabi, and Fred. A building dedicated to Tadashi is erected at the campus, which Hiro accepts the honor for his brother.